THERAPEUTICALLY TARGETING TYPE I INTERFERON DIRECTLY TO XCR1+ DENDRITIC CELLS REVEALS THE ROLE OF CDC1S IN ANTI-DRUG ANTIBODIES

Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies

Conventional type 1 dendritic cells (cDC1s) are superior in antigen cross-presentation and priming CD8+ T cell anti-tumor immunity and thus, are a target of high interest for cancer immunotherapy.Type I interferon (IFN) is a potent inducer of antigen cross-presentation, but, unfortunately, shows only modest results in the clinic given the short hal

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YOLO-V5 based deep learning approach for tooth detection and segmentation on pediatric panoramic radiographs in mixed dentition

Abstract Objectives In the interpretation of panoramic radiographs (PRs), the altitude sunscreen identification and numbering of teeth is an important part of the correct diagnosis.This study evaluates the effectiveness of YOLO-v5 in the automatic detection, segmentation, and numbering of deciduous and permanent teeth in mixed dentition pediatric p

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Crafting a prognostic nomogram for the overall survival rate of cutaneous verrucous carcinoma using the surveillance, epidemiology, and end results database

BackgroundThe aim of this study was to establish and verify simply southern cat shirt a predictive nomogram for patients with cutaneous verrucous carcinoma (CVC) who will eventually survive and to determine the accuracy of the nomogram relative to the conventional American Joint Committee on Cancer (AJCC) staging system.MethodsAssessments were perf

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Use of imperialist competitive algorithm for optimization of energy productivity and damage assessment in sugar industry: A case study

A study was conducted to optimize energy consumption and evaluate the life cycle of the sugar industry in Plant (PS) and Ratoon (RS) sugarcane farms, which were evaluated using the imperialistic competition algorithm (ICA).The data were collected through face-to-face interviews with farmers and specialized questionnaires.The energy equivalent of ea

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